ING1 regulates rRNA levels by altering nucleolar chromatin structure and mTOR localization

Epigenetic, transcriptional and signaling processes in the nucleolus regulate rRNA transcription and cell growth. We report here that the tumor suppressor ING1b binds rDNA, regulates rDNA chromatin modifications and affects nucleolar localization of mTOR to modulate rRNA levels. ING1 represses rDNA...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Rajarajacholan, Uma Karthika, Thalappilly, Subhash, Riabowol, Karl
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Gene regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389678/
https://ncbi.nlm.nih.gov/pubmed/27903908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1161
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