TLR4-induced NF-κB and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a

The AT-rich interactive domain-containing protein 5a (Arid5a) plays a critical role in autoimmunity by regulating the half-life of Interleukin-6 (IL-6) mRNA. However, the signaling pathways underlying Arid5a-mediated regulation of IL-6 mRNA stability are largely uncharacterized. Here, we found that...

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Udgivet i:Nucleic Acids Res
Main Authors: Nyati, Kishan K., Masuda, Kazuya, Zaman, Mohammad Mahabub-Uz, Dubey, Praveen K., Millrine, David, Chalise, Jaya P., Higa, Mitsuru, Li, Songling, Standley, Daron M., Saito, Kazunobu, Hanieh, Hamza, Kishimoto, Tadamitsu
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389518/
https://ncbi.nlm.nih.gov/pubmed/28168301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx064
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