Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity

Ribonucleotides (rNs) incorporated in the genome by DNA polymerases (Pols) are removed by RNase H2. Cytidine and guanosine preferentially accumulate over the other rNs. Here we show that human Pol η can incorporate cytidine monophosphate (rCMP) opposite guanine, 8-oxo-7,8-dihydroguanine, 8-methyl-2΄...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Mentegari, Elisa, Crespan, Emmanuele, Bavagnoli, Laura, Kissova, Miroslava, Bertoletti, Federica, Sabbioneda, Simone, Imhof, Ralph, Sturla, Shana J., Nilforoushan, Arman, Hübscher, Ulrich, van Loon, Barbara, Maga, Giovanni
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2017
Предметы:
Genome Integrity, Repair and Replication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389505/
https://ncbi.nlm.nih.gov/pubmed/27994034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1275
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