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Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity
Ribonucleotides (rNs) incorporated in the genome by DNA polymerases (Pols) are removed by RNase H2. Cytidine and guanosine preferentially accumulate over the other rNs. Here we show that human Pol η can incorporate cytidine monophosphate (rCMP) opposite guanine, 8-oxo-7,8-dihydroguanine, 8-methyl-2΄...
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| 出版年: | Nucleic Acids Res |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5389505/ https://ncbi.nlm.nih.gov/pubmed/27994034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1275 |
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