Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity

Ribonucleotides (rNs) incorporated in the genome by DNA polymerases (Pols) are removed by RNase H2. Cytidine and guanosine preferentially accumulate over the other rNs. Here we show that human Pol η can incorporate cytidine monophosphate (rCMP) opposite guanine, 8-oxo-7,8-dihydroguanine, 8-methyl-2΄...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Mentegari, Elisa, Crespan, Emmanuele, Bavagnoli, Laura, Kissova, Miroslava, Bertoletti, Federica, Sabbioneda, Simone, Imhof, Ralph, Sturla, Shana J., Nilforoushan, Arman, Hübscher, Ulrich, van Loon, Barbara, Maga, Giovanni
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389505/
https://ncbi.nlm.nih.gov/pubmed/27994034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1275
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