Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity

Ribonucleotides (rNs) incorporated in the genome by DNA polymerases (Pols) are removed by RNase H2. Cytidine and guanosine preferentially accumulate over the other rNs. Here we show that human Pol η can incorporate cytidine monophosphate (rCMP) opposite guanine, 8-oxo-7,8-dihydroguanine, 8-methyl-2΄...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nucleic Acids Res
मुख्य लेखकों: Mentegari, Elisa, Crespan, Emmanuele, Bavagnoli, Laura, Kissova, Miroslava, Bertoletti, Federica, Sabbioneda, Simone, Imhof, Ralph, Sturla, Shana J., Nilforoushan, Arman, Hübscher, Ulrich, van Loon, Barbara, Maga, Giovanni
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2017
विषय:
Genome Integrity, Repair and Replication
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389505/
https://ncbi.nlm.nih.gov/pubmed/27994034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1275
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