Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise

Aberrant DNA methylation is a hallmark of various human disorders, indicating that the spatial and temporal regulation of methylation readers and modifiers is imperative for development and differentiation. In particular, the cross-regulation between 5-methylcytosine binders (MBD) and modifiers (Tet...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Ludwig, Anne K., Zhang, Peng, Hastert, Florian D., Meyer, Stephanie, Rausch, Cathia, Herce, Henry D., Müller, Udo, Lehmkuhl, Anne, Hellmann, Ines, Trummer, Carina, Storm, Christian, Leonhardt, Heinrich, Cardoso, M. Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389475/
https://ncbi.nlm.nih.gov/pubmed/27923996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1197
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