Combining DNP NMR with segmental and specific labeling to study a yeast prion protein strain that is not parallel in-register

The yeast prion protein Sup35NM is a self-propagating amyloid. Despite intense study, there is no consensus on the organization of monomers within Sup35NM fibrils. Some studies point to a β-helical arrangement, whereas others suggest a parallel in-register organization. Intermolecular contacts are o...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Frederick, Kendra K., Michaelis, Vladimir K., Caporini, Marc A., Andreas, Loren B., Debelouchina, Galia T., Griffin, Robert G., Lindquist, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389306/
https://ncbi.nlm.nih.gov/pubmed/28330994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619051114
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