Ab initio solution of macromolecular crystal structures without direct methods

The majority of macromolecular crystal structures are determined using the method of molecular replacement, in which known related structures are rotated and translated to provide an initial atomic model for the new structure. A theoretical understanding of the signal-to-noise ratio in likelihood-ba...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: McCoy, Airlie J., Oeffner, Robert D., Wrobel, Antoni G., Ojala, Juha R. M., Tryggvason, Karl, Lohkamp, Bernhard, Read, Randy J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389281/
https://ncbi.nlm.nih.gov/pubmed/28325875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701640114
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