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Critical role of the cAMP-PKA pathway in hyperglycemia-induced epigenetic activation of fibrogenic program in the kidney
Hyperglycemia is a major pathogenic factor that promotes diabetic nephropathy, but the underlying mechanism remains incompletely understood. Here, we show that high glucose induced cAMP response element-binding protein (CREB)-binding protein (CBP)–mediated H3K9/14 hyperacetylation in approximately 5...
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| Published in: | FASEB J |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Federation of American Societies for Experimental Biology
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5388553/ https://ncbi.nlm.nih.gov/pubmed/28148567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601116R |
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