Disruption of the vacuolar-type H(+)-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes

The vacuolar-type H(+)-translocating ATPase (v-H(+)-ATPase) has been implicated in the amino acid-dependent activation of the mechanistic target of rapamycin complex 1 (MTORC1), an important regulator of macroautophagy. To reveal the mechanistic links between the v-H(+)-ATPase and MTORC1, we destabl...

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Publicado en:Autophagy
Autores principales: Kissing, Sandra, Rudnik, Sönke, Damme, Markus, Lüllmann-Rauch, Renate, Ichihara, Atsuhiro, Kornak, Uwe, Eskelinen, Eeva-Liisa, Jabs, Sabrina, Heeren, Jörg, De Brabander, Jef K., Haas, Albert, Saftig, Paul
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2017
Materias:
Basic Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388235/
https://ncbi.nlm.nih.gov/pubmed/28129027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1280216
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