Exploratory cohort study and meta-analysis of BIM deletion polymorphism in patients with epidermal growth factor receptor-mutant non-small-cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors

BACKGROUND: Non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations might develop primary and secondary resistance to tyrosine kinase inhibitors (TKIs). The proapoptotic protein Bcl-2-like 11 (BIM) is a key modulator of apoptosis triggered by EGFR-TKIs. The...

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Vydáno v:Onco Targets Ther
Hlavní autoři: Sun, Si, Yu, Hui, Wang, Huijie, Zhao, Xinmin, Zhao, Xintai, Wu, Xianghua, Qiao, Jie, Chang, Jianhua, Wang, Jialei
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2017
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388210/
https://ncbi.nlm.nih.gov/pubmed/28435285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S126075
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