Mechanism, consequences and therapeutic targeting of abnormal IL-15 signaling in cutaneous T-cell lymphoma

Cutaneous T-cell lymphoma (CTCL) is the most common type of primary cutaneous lymphoma. Here we report that CTCL patients show increased interleukin-15 (IL-15) in a clinical stage-dependent manner. Mechanistically, we show that Zeb1 is a transcriptional repressor of IL-15 in T-cells and that hyperme...

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Publicado en:Cancer Discov
Autores principales: Mishra, Anjali, La Perle, Krista, Kwiatkowski, Sonya, Sullivan, Laura A., Sams, Gregory H., Johns, Jessica, Curphey, Douglas P., Wen, Jing, McConnell, Kathleen, Qi, Jun, Wong, Henry, Russo, Giandomenico, Zhang, Jianying, Marcucci, Guido, Bradner, James E, Porcu, Pierluigi, Caligiuri, Michael A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388135/
https://ncbi.nlm.nih.gov/pubmed/27422033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1297
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