Impact of CFTR Modulation on Intestinal pH, Motility, and Clinical Outcomes in Patients With Cystic Fibrosis and the G551D Mutation

OBJECTIVES: A defect in bicarbonate secretion contributes to the pathophysiology of gastrointestinal complications in patients with cystic fibrosis (CF). We measured gastrointestinal pH, clinical outcomes, and intestinal transit profiles in patients with the G551D mutation before and after treatment...

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Detalhes bibliográficos
Publicado no:Clin Transl Gastroenterol
Main Authors: Gelfond, Daniel, Heltshe, Sonya, Ma, Changxing, Rowe, Steven M, Frederick, Carla, Uluer, Ahmet, Sicilian, Leonard, Konstan, Michael, Tullis, Elizabeth, Roach, R N Christine, Griffin, Katherine, Joseloff, Elizabeth, Borowitz, Drucy
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Contributions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387753/
https://ncbi.nlm.nih.gov/pubmed/28300821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ctg.2017.10
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