Atorvastatin does not protect against ischemia-reperfusion damage in cholestatic rat livers

BACKGROUND: Extrahepatic cholestasis sensitizes the liver to ischemia/reperfusion (I/R) injury during surgery for perihilar cholangiocarcinoma. It is associated with pre-existent sterile inflammation, microvascular perfusion defects, and impaired energy status. Statins have been shown to protect aga...

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Udgivet i:BMC Surg
Main Authors: Wiggers, Jimme K., van Golen, Rowan F., Verheij, Joanne, Dekker, Annemiek M., van Gulik, Thomas M., Heger, Michal
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387220/
https://ncbi.nlm.nih.gov/pubmed/28399849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12893-017-0235-9
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