Quantitative proteomic analysis of Parkin substrates in Drosophila neurons

BACKGROUND: Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Parkinson’s Disease (PD). In cell culture models, Parkin is recruited to acutely depolarised mitochondria by PINK1. PINK1 activates Parkin activity leading to ubiquitination of multiple proteins, which in turn...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Martinez, Aitor, Lectez, Benoit, Ramirez, Juanma, Popp, Oliver, Sutherland, James D., Urbé, Sylvie, Dittmar, Gunnar, Clague, Michael J., Mayor, Ugo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387213/
https://ncbi.nlm.nih.gov/pubmed/28399880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0170-3
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