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Effects of miR‐145‐5p through NRAS on the cell proliferation, apoptosis, migration, and invasion in melanoma by inhibiting MAPK and PI3K/AKT pathways

We aimed to detect the effects of miR‐145‐5p on the cell proliferation, apoptosis, migration, and invasion in NRAS‐mutant, BRAF‐mutant, and wild‐type melanoma cells, in order to figure out the potential mechanisms and provide a novel therapeutic target of melanoma. RT‐qPCR and western blot were used...

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Библиографические подробности
Опубликовано в: :Cancer Med
Главные авторы: Liu, Sha, Gao, Guozhen, Yan, Dexiong, Chen, Xiangjun, Yao, Xingwei, Guo, Shuzhong, Li, Guirong, Zhao, Yu
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387172/
https://ncbi.nlm.nih.gov/pubmed/28332309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1030
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