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Effects of miR‐145‐5p through NRAS on the cell proliferation, apoptosis, migration, and invasion in melanoma by inhibiting MAPK and PI3K/AKT pathways

We aimed to detect the effects of miR‐145‐5p on the cell proliferation, apoptosis, migration, and invasion in NRAS‐mutant, BRAF‐mutant, and wild‐type melanoma cells, in order to figure out the potential mechanisms and provide a novel therapeutic target of melanoma. RT‐qPCR and western blot were used...

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Dettagli Bibliografici
Pubblicato in:Cancer Med
Autori principali: Liu, Sha, Gao, Guozhen, Yan, Dexiong, Chen, Xiangjun, Yao, Xingwei, Guo, Shuzhong, Li, Guirong, Zhao, Yu
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387172/
https://ncbi.nlm.nih.gov/pubmed/28332309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1030
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