Crystal Structure of Complete Rhinovirus RNA Polymerase Suggests Front Loading of Protein Primer

Picornaviruses utilize virally encoded RNA polymerase and a uridylylated protein primer to ensure replication of the entire viral genome. The molecular details of this mechanism are not well understood due to the lack of structural information. We report the crystal structure of human rhinovirus 16...

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Bibliographische Detailangaben
Hauptverfasser: Appleby, Todd C., Luecke, Hartmut, Shim, Jae Hoon, Wu, Jim Z., Cheney, I. Wayne, Zhong, Weidong, Vogeley, Lutz, Hong, Zhi, Yao, Nanhua
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC538717/
https://ncbi.nlm.nih.gov/pubmed/15596823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.1.277-288.2005
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