Crystal Structure of Complete Rhinovirus RNA Polymerase Suggests Front Loading of Protein Primer

Picornaviruses utilize virally encoded RNA polymerase and a uridylylated protein primer to ensure replication of the entire viral genome. The molecular details of this mechanism are not well understood due to the lack of structural information. We report the crystal structure of human rhinovirus 16...

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Detalhes bibliográficos
Main Authors: Appleby, Todd C., Luecke, Hartmut, Shim, Jae Hoon, Wu, Jim Z., Cheney, I. Wayne, Zhong, Weidong, Vogeley, Lutz, Hong, Zhi, Yao, Nanhua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC538717/
https://ncbi.nlm.nih.gov/pubmed/15596823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.1.277-288.2005
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