Crystal Structure of Complete Rhinovirus RNA Polymerase Suggests Front Loading of Protein Primer

Picornaviruses utilize virally encoded RNA polymerase and a uridylylated protein primer to ensure replication of the entire viral genome. The molecular details of this mechanism are not well understood due to the lack of structural information. We report the crystal structure of human rhinovirus 16...

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Bibliographic Details
Published in:J Virol
Main Authors: Appleby, Todd C., Luecke, Hartmut, Shim, Jae Hoon, Wu, Jim Z., Cheney, I. Wayne, Zhong, Weidong, Vogeley, Lutz, Hong, Zhi, Yao, Nanhua
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2005
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC538717/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15596823/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.79.1.277-288.2005
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