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Crystal Structure of Complete Rhinovirus RNA Polymerase Suggests Front Loading of Protein Primer

Picornaviruses utilize virally encoded RNA polymerase and a uridylylated protein primer to ensure replication of the entire viral genome. The molecular details of this mechanism are not well understood due to the lack of structural information. We report the crystal structure of human rhinovirus 16...

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Udgivet i:J Virol
Principais autores: Appleby, Todd C., Luecke, Hartmut, Shim, Jae Hoon, Wu, Jim Z., Cheney, I. Wayne, Zhong, Weidong, Vogeley, Lutz, Hong, Zhi, Yao, Nanhua
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2005
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC538717/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15596823/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.79.1.277-288.2005
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