Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells

Aberrant signaling transduction induced by mutant KRAS proteins occurs in 20∼30% of non-small cell lung cancer (NSCLC), however, a direct and effective pharmacological inhibitor targeting KRAS has not yet reached the clinic to date. Honokiol, a small molecular polyphenol natural biophenolic compound...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Luo, Lian-Xiang, Li, Ying, Liu, Zhong-Qiu, Fan, Xing-Xing, Duan, Fu-Gang, Li, Run-Ze, Yao, Xiao-Jun, Leung, Elaine Lai-Han, Liu, Liang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387050/
https://ncbi.nlm.nih.gov/pubmed/28443025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00199
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