Broad spectrum efficacy with LY2969822, an oral prodrug of metabotropic glutamate 2/3 receptor agonist LY2934747, in rodent pain models

BACKGROUND AND PURPOSE: A body of evidence suggests activation of metabotropic glutamate 2/3 (mGlu(2/3)) receptors would be an effective analgesic in chronic pain conditions. Thus, the analgesic properties of a novel mGlu(2/3) receptor agonist prodrug were investigated. EXPERIMENTAL APPROACH: After...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Johnson, Michael P, Muhlhauser, Mark A, Nisenbaum, Eric S, Simmons, Rosa M A, Forster, Beth M, Knopp, Kelly L, Yang, Lijuan, Morrow, Denise, Li, Dominic L, Kennedy, Jeffrey D, Swanson, Steven, Monn, James A
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386998/
https://ncbi.nlm.nih.gov/pubmed/28177520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13740
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