Importance of Arginine 20 of the Swine Vesicular Disease Virus 2A Protease for Activity and Virulence

A major virulence determinant of swine vesicular disease virus (SVDV), an Enterovirus that causes an acute vesicular disease, has been mapped to residue 20 of the 2A protease. The SVDV 2A protease cleaves the 1D-2A junction in the viral polyprotein, induces cleavage of translation initiation factor...

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Detalhes bibliográficos
Main Authors: Inoue, Toru, Alexandersen, Soren, Clark, Angela T., Murphy, Ciara, Quan, Melvyn, Reid, Scott M., Sakoda, Yoshihiro, Johns, Helen L., Belsham, Graham J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC538687/
https://ncbi.nlm.nih.gov/pubmed/15596836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.1.428-440.2005
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