Ochratoxin A induces ER stress and apoptosis in mesangial cells via a NADPH oxidase-derived reactive oxygen species-mediated calpain activation pathway

Ochratoxin A (OTA) contaminated food increases reactive oxygen species (ROS) production in glomerulus and causes glomerulopathy. The molecular mechanisms still remain uncertain. In this study, we used mouse and rat glomerular mesangial cells and delineate the signaling pathway behind the OTA-trigger...

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Udgivet i:Oncotarget
Main Authors: Sheu, Meei-Ling, Shen, Chin-Chang, Chen, Yuan-Siao, Chiang, Chih-Kang
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386691/
https://ncbi.nlm.nih.gov/pubmed/28038445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14270
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