Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells

Acquired resistance is a common phenomenon for HCC patients who undergone sorafenib treatment, however the mechanism by which acquired resistance develops remains elusive. In this study, we found that GRP78 could be detected in the serum samples of HCC patients and the conditional medium of multiple...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Li, Rui, Yanjiao, Gu, Wubin, He, Yue, Wang, Jianhua, Huang, Huachuan, Zheng, Rongjian, Su, Zhidong, Luan
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386689/
https://ncbi.nlm.nih.gov/pubmed/28423613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15223
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