Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway

The imbalance between Th17 and Treg cells substantially contributes to the intestinal immune disturbance and subsequent tissue injury in ulcerative colitis. The triterpenoid-rich fraction of Centella asiatica was able to ameliorate dextran sulfate sodium-induced colitis in mice. Here we explored its...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Xu, Xiaotian, Wang, Yuhui, Wei, Zhifeng, Wei, Wenhui, Zhao, Peng, Tong, Bei, Xia, Yufeng, Dai, Yue
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386545/
https://ncbi.nlm.nih.gov/pubmed/28358365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.150
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