FTO is required for myogenesis by positively regulating mTOR-PGC-1α pathway-mediated mitochondria biogenesis

Global germ line loss of fat mass- and obesity-associated (FTO) gene results in both the reduction of fat mass and lean mass in mice. The role of FTO in adipogenesis has been proposed, however, that in myogenesis has not. Skeletal muscle is the main component of body lean mass, so its connection wit...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Wang, Xiaobo, Huang, Ning, Yang, Min, Wei, Dandan, Tai, Haoran, Han, Xiaojuan, Gong, Hui, Zhou, Jiao, Qin, Jianqiong, Wei, Xiawei, Chen, Honghan, Fang, Tingting, Xiao, Hengyi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386528/
https://ncbi.nlm.nih.gov/pubmed/28333151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.122
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