Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis

Delocalized lipophilic cations (DLCs) selectively accumulate in cancer cell mitochondria and have long been explored for therapeutic applications. Although targeted effects to cancer cells are demonstrated in vitro, non-specific toxicities in vivo have hampered clinical development. Identifying the...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Yang, Ning, Weinfeld, Michael, Lemieux, Hélène, Montpetit, Ben, Goping, Ing Swie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386467/
https://ncbi.nlm.nih.gov/pubmed/28151485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.19
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