Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis

Delocalized lipophilic cations (DLCs) selectively accumulate in cancer cell mitochondria and have long been explored for therapeutic applications. Although targeted effects to cancer cells are demonstrated in vitro, non-specific toxicities in vivo have hampered clinical development. Identifying the...

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Bibliografiska uppgifter
I publikationen:Cell Death Dis
Huvudupphovsmän: Yang, Ning, Weinfeld, Michael, Lemieux, Hélène, Montpetit, Ben, Goping, Ing Swie
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386467/
https://ncbi.nlm.nih.gov/pubmed/28151485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.19
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