Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson's disease

Rapamycin protects mice against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced loss of dopaminergic neurons, which is an established model for Parkinson's disease. We demonstrated that rapamycin preserves astrocytic expression of glutamate transporters and glutamate reuptake. The p...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Zhang, Yunlong, He, Xiaoliang, Wu, Xiaojuan, Lei, Ming, Wei, Zhiyun, Zhang, Xiuping, Wen, Lei, Xu, Pingyi, Li, Shaomin, Qu, Shaogang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386462/
https://ncbi.nlm.nih.gov/pubmed/28182002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.491
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