Translational upregulation of Aurora-A by hnRNP Q1 contributes to cell proliferation and tumorigenesis in colorectal cancer

By using RNA-immunoprecipitation assay following next-generation sequencing, a group of cell cycle-related genes targeted by hnRNP Q1 were identified, including Aurora-A kinase. Overexpressed hnRNP Q1 can upregulate Aurora-A protein, but not alter the mRNA level, through enhancing the translational...

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Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Lai, Chien-Hsien, Huang, Yu-Chuan, Lee, Jenq-Chang, Tseng, Joseph Ta-Chien, Chang, Kung-Chao, Chen, Yen-Ju, Ding, Nai-Jhu, Huang, Pao-Hsuan, Chang, Wen-Chang, Lin, Bo-Wen, Chen, Ruo-Yu, Wang, Yu-Chu, Lai, Yi-Chien, Hung, Liang-Yi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386382/
https://ncbi.nlm.nih.gov/pubmed/28079881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.479
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