Inhibition of Stat3 by a Small Molecule Inhibitor Slows Vision Loss in a Rat Model of Diabetic Retinopathy

PURPOSE: Diabetic retinopathy is a leading cause of vision loss. Previous studies have shown signaling pathways mediated by Stat3 (signal transducer and activator of transcription 3) play a primary role in diabetic retinopathy progression. This study tested CLT-005, a small molecule inhibitor of Sta...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Vanlandingham, Phillip A., Nuno, Didier J., Quiambao, Alexander B., Phelps, Eric, Wassel, Ronald A., Ma, Jian-Xing, Farjo, Krysten M., Farjo, Rafal A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2017
Assuntos:
Physiology and Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386345/
https://ncbi.nlm.nih.gov/pubmed/28395025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-20641
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