Natural non-homologous recombination led to the emergence of a duplicated V3-NS5A region in HCV-1b strains associated with hepatocellular carcinoma

BACKGROUND: The emergence of new strains in RNA viruses is mainly due to mutations or intra and inter-genotype homologous recombination. Non-homologous recombinations may be deleterious and are rarely detected. In previous studies, we identified HCV-1b strains bearing two tandemly repeated V3 region...

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Publicado no:PLoS One
Main Authors: Le Guillou-Guillemette, Hélène, Pivert, Adeline, Bouthry, Elise, Henquell, Cécile, Petsaris, Odile, Ducancelle, Alexandra, Veillon, Pascal, Vallet, Sophie, Alain, Sophie, Thibault, Vincent, Abravanel, Florence, Rosenberg, Arielle A., André-Garnier, Elisabeth, Bour, Jean-Baptiste, Baazia, Yazid, Trimoulet, Pascale, André, Patrice, Gaudy-Graffin, Catherine, Bettinger, Dominique, Larrat, Sylvie, Signori-Schmuck, Anne, Saoudin, Hénia, Pozzetto, Bruno, Lagathu, Gisèle, Minjolle-Cha, Sophie, Stoll-Keller, Françoise, Pawlotsky, Jean-Michel, Izopet, Jacques, Payan, Christopher, Lunel-Fabiani, Françoise, Lemaire, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386276/
https://ncbi.nlm.nih.gov/pubmed/28394908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174651
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