Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and methods for assessing them

Mendelian randomization (MR), the use of genetic variants as instrumental variables (IVs) to test causal effects, is increasingly used in aetiological epidemiology. Few of the methodological developments in MR have considered the specific situation of using genetic IVs to test the causal effect of e...

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Detalles Bibliográficos
Publicado en:Wellcome Open Res
Main Authors: Lawlor, Deborah, Richmond, Rebecca, Warrington, Nicole, McMahon, George, Davey Smith, George, Bowden, Jack, Evans, David M
Formato: Artigo
Idioma:Inglês
Publicado: F1000Research 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386135/
https://ncbi.nlm.nih.gov/pubmed/28405635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/wellcomeopenres.10567.1
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