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Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene

We and others have previously identified a group of genes, dubbed “disallowed,” whose expression is markedly lower in pancreatic islets than in other mammalian cell types. Forced mis-expression of several members of this family leads to defective insulin secretion, demonstrating the likely importanc...

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Publicado en:Front Genet
Autores principales: Pullen, Timothy J., Huising, Mark O., Rutter, Guy A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385341/
https://ncbi.nlm.nih.gov/pubmed/28443133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2017.00041
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