Periprosthetic UHMWPE Wear Debris Induces Inflammation, Vascularization, and Innervation After Total Disc Replacement in the Lumbar Spine

BACKGROUND: The pathophysiology and mechanisms driving the generation of unintended pain after total disc replacement (TDR) remain unexplored. Ultrahigh-molecular-weight polyethylene (UHMWPE) wear debris from TDRs is known to induce inflammation, which may result in pain. QUESTIONS/PURPOSES: The pur...

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Veröffentlicht in:Clin Orthop Relat Res
Hauptverfasser: Veruva, Sai Y., Lanman, Todd H., Isaza, Jorge E., Freeman, Theresa A., Kurtz, Steven M., Steinbeck, Marla J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2016
Schlagworte:
Symposium: Advances in Polyethylene Biomaterials
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384906/
https://ncbi.nlm.nih.gov/pubmed/27488379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11999-016-4996-8
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