Analysis of transcriptional variability in a large human iPSC library reveals genetic and non-genetic determinants of heterogeneity

Variability in induced pluripotent stem cell (iPSC) lines remains a concern for disease modeling and regenerative medicine. We have used RNA sequencing analysis and linear mixed models to examine the sources of gene expression variability in 317 human iPSC lines from 101 individuals. We found that ~...

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Publicado no:Cell Stem Cell
Main Authors: Carcamo-Orive, Ivan, Hoffman, Gabriel E., Cundiff, Paige, Beckmann, Noam D., D’Souza, Sunita, Knowles, Joshua W., Patel, Achchhe, Papatsenko, Dimitri, Abbasi, Fahim, Reaven, Gerald M., Whalen, Sean, Lee, Philip, Shahbazi, Mohammad, Henrion, Marc, Zhu, Kuixi, Wang, Sven, Roussos, Panos, Schadt, Eric E., Pandey, Gaurav, Chang, Rui, Quertermous, Thomas, Lemischka, Ihor
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384872/
https://ncbi.nlm.nih.gov/pubmed/28017796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.11.005
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