Trimeric gp120-specific bovine monoclonal antibodies require cysteine and aromatic residues in CDRH3 for high affinity binding to HIV Env

We isolated HIV-1 Envelope (Env)-specific memory B cells from a cow that had developed high titer polyclonal immunoglobulin G (IgG) with broad neutralizing activity after a long duration vaccination with HIV-1(AD8) Env gp140 trimers. We cloned the bovine IgG matched heavy (H) and light (L) chain var...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Heydarchi, Behnaz, Center, Rob J., Bebbington, Jonathan, Cuthbertson, Jack, Gonelli, Christopher, Khoury, Georges, Mackenzie, Charlene, Lichtfuss, Marit, Rawlin, Grant, Muller, Brian, Purcell, Damian
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384801/
https://ncbi.nlm.nih.gov/pubmed/27996375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1270491
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