A high-performance, non-radioactive potency assay for measuring cytotoxicity: A full substitute of the chromium-release assay targeting the regulatory-compliance objective

Standardized and biologically relevant potency assays are required by the regulatory authorities for the characterization and quality control of therapeutic antibodies. As critical mechanisms of action (MoA) of antibodies, the antibody-dependent cell-meditated cytotoxicity (ADCC) and complement-depe...

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Опубликовано в: :MAbs
Главные авторы: Rossignol, Alexis, Bonnaudet, Véronique, Clémenceau, Béatrice, Vié, Henri, Bretaudeau, Laurent
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2017
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Reports
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384798/
https://ncbi.nlm.nih.gov/pubmed/28281922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1286435
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