Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner

There is a significantly higher risk for type II diabetes in HIV-1 carriers, albeit the molecular mechanism for this HIV-related pathology remains enigmatic. The 52 amino acid HIV-1 p6 Gag protein is synthesized as the C-terminal part of the Gag polyprotein Pr55. In this context, p6 promotes virus r...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Hahn, Friedrich, Schmalen, Adrian, Setz, Christian, Friedrich, Melanie, Schlößer, Stefan, Kölle, Julia, Spranger, Robert, Rauch, Pia, Fraedrich, Kirsten, Reif, Tatjana, Karius-Fischer, Julia, Balasubramanyam, Ashok, Henklein, Petra, Fossen, Torgils, Schubert, Ulrich
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384750/
https://ncbi.nlm.nih.gov/pubmed/28388673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174254
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items