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Mutation of the Highly Conserved Ser-40 of the HIV-1 p6 Gag Protein to Phe Causes the Formation of a Hydrophobic Patch, Enhances Membrane Association, and Polyubiquitination of Gag

The HIV-1 p6 Gag protein contains two late assembly (l-) domains that recruit proteins of the endosomal sorting complex required for transport (ESCRT) pathway to mediate membrane fission between the nascent virion and the cell membrane. It was recently demonstrated that mutation of the highly conser...

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Detalhes bibliográficos
Main Authors: Hahn, Friedrich, Setz, Christian, Friedrich, Melanie, Rauch, Pia, Solbak, Sara Marie, Frøystein, Nils Åge, Henklein, Petra, Votteler, Jörg, Fossen, Torgils, Schubert, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4213559/
https://ncbi.nlm.nih.gov/pubmed/25279819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v6103738
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