Obinutuzumab-mediated high-affinity ligation of FcγRIIIA/CD16 primes NK cells for IFNγ production

Natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC), based on the recognition of IgG-opsonized targets by the low-affinity receptor for IgG FcγRIIIA/CD16, represents one of the main mechanisms by which therapeutic antibodies (mAbs) mediate their antitumor effects. Besid...

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Dettagli Bibliografici
Pubblicato in:Oncoimmunology
Autori principali: Capuano, Cristina, Pighi, Chiara, Molfetta, Rosa, Paolini, Rossella, Battella, Simone, Palmieri, Gabriella, Giannini, Giuseppe, Belardinilli, Francesca, Santoni, Angela, Galandrini, Ricciarda
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2017
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384385/
https://ncbi.nlm.nih.gov/pubmed/28405525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1290037
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