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Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis

The platelet-derived growth factor receptor alpha (PDGFRα) exhibits divergent effects in skeletal muscle. At physiological levels, signaling through this receptor promotes muscle development in growing embryos and proper angiogenesis in regenerating adult muscle.(1,2) However, both increased PDGF li...

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Publicat a:Nature
Autors principals: Mueller, Alisa A., van Velthoven, Cindy T., Fukumoto, Kathryn D., Cheung, Tom H., Rando, Thomas A.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384334/
https://ncbi.nlm.nih.gov/pubmed/27894125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20160
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