Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations

The vast majority of genome-wide association studies (GWASs) are performed in Europeans, and their transferability to other populations is dependent on many factors (e.g., linkage disequilibrium, allele frequencies, genetic architecture). As medical genomics studies become increasingly large and div...

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Udgivet i:Am J Hum Genet
Main Authors: Martin, Alicia R., Gignoux, Christopher R., Walters, Raymond K., Wojcik, Genevieve L., Neale, Benjamin M., Gravel, Simon, Daly, Mark J., Bustamante, Carlos D., Kenny, Eimear E.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384097/
https://ncbi.nlm.nih.gov/pubmed/28366442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2017.03.004
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