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Large-Scale trans-eQTLs Affect Hundreds of Transcripts and Mediate Patterns of Transcriptional Co-regulation

Efforts to decipher the causal relationships between differences in gene regulation and corresponding differences in phenotype have been stymied by several basic technical challenges. Although detecting local, cis-eQTLs is now routine, trans-eQTLs, which are distant from the genes of origin, are far...

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Detalhes bibliográficos
Publicado no:Am J Hum Genet
Main Authors: Brynedal, Boel, Choi, JinMyung, Raj, Towfique, Bjornson, Robert, Stranger, Barbara E., Neale, Benjamin M., Voight, Benjamin F., Cotsapas, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384037/
https://ncbi.nlm.nih.gov/pubmed/28285767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2017.02.004
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