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Addressing a weakness of anticancer therapy with mitosis inhibitors: Mitotic slippage

Mitosis inhibitors, which include antimicrotubule drugs, are chemotherapy agents that induce the arrest and apoptosis of mitotic cells. Mitotic slippage, in which mitotically arrested cells exit mitosis, limits the effectiveness of mitosis inhibitors. We have discovered that the CRL2(ZYG11A/B) ubiqu...

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Foilsithe in:Mol Cell Oncol
Main Authors: Balachandran, Riju S., Kipreos, Edward T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Taylor & Francis 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5383364/
https://ncbi.nlm.nih.gov/pubmed/28401182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1277293
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