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Prediction of hERG Liability: Using SVM Classification, Bootstrapping and Jackknifing
Drug-induced QT prolongation leads to life-threatening cardiotoxicity, mostly through blockage of the human ether-a-go-go-related gene (hERG) encoded potassium ion (K(+)) channels. The hERG channel is one of the most important antitargets to be addressed in the early stage of drug discovery process,...
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| Pubblicato in: | Mol Inform |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5382096/ https://ncbi.nlm.nih.gov/pubmed/28000393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/minf.201600126 |
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