Insulin signaling regulates the FoxM1/PLK1/CENP-A pathway to promote adaptive pancreatic β-cell proliferation

Investigation of cell cycle kinetics in mammalian pancreatic β-cells has mostly focused on transition from the quiescent (G0) to G1 phase. Here we report that centromere protein A (CENP-A), which is required for chromosome segregation during the M-phase, is necessary for adaptive β-cell proliferatio...

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Udgivet i:Cell Metab
Main Authors: Shirakawa, Jun, Fernandez, Megan, Takatani, Tomozumi, El Ouaamari, Abdelfattah, Jungtrakoon, Prapaporn, Okawa, Erin R., Zhang, Wei, Yi, Peng, Doria, Alessandro, Kulkarni, Rohit N.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382039/
https://ncbi.nlm.nih.gov/pubmed/28286049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.02.004
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