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Acute ethanol increases IGF-I-induced phosphorylation of ERKs by enhancing recruitment of p52-Shc to the Grb2/Shc complex

Ethanol plays a detrimental role in the development of the brain. Multiple studies have shown that ethanol inhibits insulin-like growth factor I receptor (IGF-IR) function. Because the IGF-IR contributes to brain development by supporting neural growth, survival, and differentiation, we sought to de...

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Detalhes bibliográficos
Publicado no:J Cell Physiol
Main Authors: Dean, Matthew, Lassak, Adam, Wilk, Anna, Zapata, Adriana, Marrero, Luis, Molina, Patricia, Reiss, Krzysztof
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5381968/
https://ncbi.nlm.nih.gov/pubmed/27607558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.25586
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