ATRX Loss Promotes Tumor Growth and Impairs Non-Homologous End Joining DNA Repair in Glioma

Recent work in human glioblastoma (GBM) has documented recurrent mutations in the histone chaperone protein ATRX. We developed an animal model of ATRX-deficient GBM and show that loss of ATRX reduces median survival and increases genetic instability. Further, analysis of genome-wide data for human g...

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Publicado no:Sci Transl Med
Main Authors: Koschmann, Carl, Calinescu, Anda-Alexandra, Nunez, Felipe J., Mackay, Alan, Fazal-Salom, Janet, Thomas, Daniel, Mendez, Flor, Kamran, Neha, Dzaman, Marta, Mulpuri, Lakshman, Krasinkiewicz, Johnathon, Doherty, Robert, Lemons, Rosemary, Brosnan-Cashman, Jackie A., Li, Youping, Roh, Soyeon, Zhao, Lili, Appelman, Henry, Ferguson, David, Gorbunova, Vera, Meeker, Alan, Jones, Chris, Lowenstein, Pedro R., Castro, Maria G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5381643/
https://ncbi.nlm.nih.gov/pubmed/26936505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac8228
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