Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes

AIMS: Cardiomyocytes (CMs) generated from human induced pluripotent stem cells (hiPSCs) are increasingly used in disease modelling and drug evaluation. However, they are typically a heterogeneous mix of ventricular-, atrial-, and nodal-like cells based on action potentials (APs) and gene expression....

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Dettagli Bibliografici
Pubblicato in:Eur Heart J
Autori principali: Chen, Zhifen, Xian, Wenying, Bellin, Milena, Dorn, Tatjana, Tian, Qinghai, Goedel, Alexander, Dreizehnter, Lisa, Schneider, Christine M., Ward-van Oostwaard, Dorien, Ng, Judy King Man, Hinkel, Rabea, Pane, Luna Simona, Mummery, Christine L., Lipp, Peter, Moretti, Alessandra, Laugwitz, Karl-Ludwig, Sinnecker, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
Basic Science
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5381588/
https://ncbi.nlm.nih.gov/pubmed/28182242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehw189
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