Polysulfides (H(2)S(n)) produced from the interaction of hydrogen sulfide (H(2)S) and nitric oxide (NO) activate TRPA1 channels

Hydrogen sulfide (H(2)S) exerts synergistic effects with another gaseous signaling molecule nitric oxide (NO) on ion channels and vasculature. However, the mechanism of the synergy is not well understood. Here, we show that the interaction between H(2)S and NO generates polysulfides (H(2)S(n)), whic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Miyamoto, Ryo, Koike, Shin, Takano, Yoko, Shibuya, Norihiro, Kimura, Yuka, Hanaoka, Kenjiro, Urano, Yasuteru, Ogasawara, Yuki, Kimura, Hideo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380989/
https://ncbi.nlm.nih.gov/pubmed/28378773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45995
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