Mediation of transitional B cell maturation in the absence of functional Bruton’s tyrosine kinase

X-linked immune-deficient (Xid) mice, carrying a mutation in Bruton’s tyrosine kinase (Btk), have multiple B cell lineage differentiation defects. We now show that, while Xid mice showed only mild reduction in the frequency of the late transitional (T2) stage of peripheral B cells, the defect became...

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Publicado en:Sci Rep
Main Authors: Tanwar, Shalini, Dhar, Atika, Varanasi, Vineeth, Mukherjee, Tapas, Boppana, Ramanamurthy, Basak, Soumen, Bal, Vineeta, George, Anna, Rath, Satyajit
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380950/
https://ncbi.nlm.nih.gov/pubmed/28378771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46029
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